PoplarV1, Main, Exploration, bibRecord, 000C42

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo.

Identifieur interne : 000C42 ( Main/Exploration ); précédent : 000C41; suivant : 000C43

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo.

Auteurs : M J Mchugh [Australie] ; P D Mcgorry [Australie] ; H P Yuen [Australie] ; I B Hickie [Australie] ; A. Thompson [Royaume-Uni] ; L. De Haan [Pays-Bas] ; N. Mossaheb [Autriche] ; S. Smesny [Allemagne] ; A. Lin [Australie] ; C. Markulev [Australie] ; M. Schloegelhofer [Autriche] ; S J Wood [Australie] ; D. Nieman [Pays-Bas] ; J A Hartmann [Australie] ; M. Nordentoft [Danemark] ; M. Sch Fer [Australie] ; G P Amminger [Australie] ; A. Yung [Royaume-Uni] ; B. Nelson [Australie]

Source :

Schizophrenia research [ 1573-2509 ] ; 2018.

RBID : pubmed:29055567

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Coopération internationale (MeSH), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Symptômes prodromiques (MeSH), Troubles psychotiques (diagnostic), Troubles psychotiques (psychologie), Troubles psychotiques (épidémiologie), Échelles d'évaluation en psychiatrie (MeSH), Études de cohortes (MeSH).
MESH :
- diagnostic : Troubles psychotiques.
- psychologie : Troubles psychotiques.
- épidémiologie : Troubles psychotiques.
- Adolescent, Adulte, Coopération internationale, Femelle, Humains, Jeune adulte, Mâle, Symptômes prodromiques, Échelles d'évaluation en psychiatrie, Études de cohortes.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Cohort Studies (MeSH), Female (MeSH), Humans (MeSH), International Cooperation (MeSH), Male (MeSH), Prodromal Symptoms (MeSH), Psychiatric Status Rating Scales (MeSH), Psychotic Disorders (diagnosis), Psychotic Disorders (epidemiology), Psychotic Disorders (psychology), Young Adult (MeSH).
MESH :
- diagnosis : Psychotic Disorders.
- epidemiology : Psychotic Disorders.
- psychology : Psychotic Disorders.
- Adolescent, Adult, Cohort Studies, Female, Humans, International Cooperation, Male, Prodromal Symptoms, Psychiatric Status Rating Scales, Young Adult.

Abstract

Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. Specifically, most UHR individuals will not develop psychosis, but will experience high rates of non-psychotic disorders, persistent APS and poor long-term functional outcomes. Rather than focus on transition, the present study investigated whether UHR groups differ in their broader clinical risk profile by examining baseline clinical characteristics and long-term outcomes other than transition to psychosis. Four UHR groups were defined: Trait-only, APS-only, Trait+APS, and any BLIPS. Participants (N=702) were recruited upon entry to early intervention services and followed-up over a period of up to 13years (mean=4.53, SD=3.84). The groups evidenced similar symptom severity (SANS for negative symptoms, BPRS for positive and depression/anxiety symptoms) and psychosocial functioning (SOFAS, GAF, QLS) at baseline and follow-up as well as similar prevalence of non-psychotic disorders at follow-up. Our findings demonstrate that UHR groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis, and consequently support maintaining the existing UHR criteria.

DOI: 10.1016/j.schres.2017.09.003
PubMed: 29055567

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo.</title>
<author><name sortKey="Mchugh, M J" sort="Mchugh, M J" uniqKey="Mchugh M" first="M J" last="Mchugh">M J Mchugh</name>
<affiliation wicri:level="1"><nlm:affiliation>Orygen, The National Centre for Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia. Electronic address: meredith.mchugh@gmail.com.</nlm:affiliation>
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<author><name sortKey="Mcgorry, P D" sort="Mcgorry, P D" uniqKey="Mcgorry P" first="P D" last="Mcgorry">P D Mcgorry</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Yuen, H P" sort="Yuen, H P" uniqKey="Yuen H" first="H P" last="Yuen">H P Yuen</name>
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<author><name sortKey="Thompson, A" sort="Thompson, A" uniqKey="Thompson A" first="A" last="Thompson">A. Thompson</name>
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<author><name sortKey="De Haan, L" sort="De Haan, L" uniqKey="De Haan L" first="L" last="De Haan">L. De Haan</name>
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<wicri:regionArea>Department of Psychiatry, Early Psychosis Section, Academic Medical Centre, University of Amsterdam</wicri:regionArea>
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<author><name sortKey="Mossaheb, N" sort="Mossaheb, N" uniqKey="Mossaheb N" first="N" last="Mossaheb">N. Mossaheb</name>
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<author><name sortKey="Smesny, S" sort="Smesny, S" uniqKey="Smesny S" first="S" last="Smesny">S. Smesny</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
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<author><name sortKey="Lin, A" sort="Lin, A" uniqKey="Lin A" first="A" last="Lin">A. Lin</name>
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<wicri:noRegion>The University of Western Australia</wicri:noRegion>
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<author><name sortKey="Markulev, C" sort="Markulev, C" uniqKey="Markulev C" first="C" last="Markulev">C. Markulev</name>
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<author><name sortKey="Schloegelhofer, M" sort="Schloegelhofer, M" uniqKey="Schloegelhofer M" first="M" last="Schloegelhofer">M. Schloegelhofer</name>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University Vienna, Austria; Department of Child and Adolescent Psychiatry, Medical University Vienna, Vienna</wicri:regionArea>
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<author><name sortKey="Wood, S J" sort="Wood, S J" uniqKey="Wood S" first="S J" last="Wood">S J Wood</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, University of Birmingham, Birmingham, UK; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
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<author><name sortKey="Nieman, D" sort="Nieman, D" uniqKey="Nieman D" first="D" last="Nieman">D. Nieman</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Hartmann, J A" sort="Hartmann, J A" uniqKey="Hartmann J" first="J A" last="Hartmann">J A Hartmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Orygen, The National Centre for Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen, The National Centre for Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
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<author><name sortKey="Nordentoft, M" sort="Nordentoft, M" uniqKey="Nordentoft M" first="M" last="Nordentoft">M. Nordentoft</name>
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<country xml:lang="fr">Danemark</country>
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<front><div type="abstract" xml:lang="en">Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. Specifically, most UHR individuals will not develop psychosis, but will experience high rates of non-psychotic disorders, persistent APS and poor long-term functional outcomes. Rather than focus on transition, the present study investigated whether UHR groups differ in their broader clinical risk profile by examining baseline clinical characteristics and long-term outcomes other than transition to psychosis. Four UHR groups were defined: Trait-only, APS-only, Trait+APS, and any BLIPS. Participants (N=702) were recruited upon entry to early intervention services and followed-up over a period of up to 13years (mean=4.53, SD=3.84). The groups evidenced similar symptom severity (SANS for negative symptoms, BPRS for positive and depression/anxiety symptoms) and psychosocial functioning (SOFAS, GAF, QLS) at baseline and follow-up as well as similar prevalence of non-psychotic disorders at follow-up. Our findings demonstrate that UHR groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis, and consequently support maintaining the existing UHR criteria.</div>
</front>
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<DateCompleted><Year>2018</Year>
<Month>12</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>11</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>195</Volume>
<PubDate><Year>2018</Year>
<Month>05</Month>
</PubDate>
</JournalIssue>
<Title>Schizophrenia research</Title>
<ISOAbbreviation>Schizophr Res</ISOAbbreviation>
</Journal>
<ArticleTitle>The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo.</ArticleTitle>
<Pagination><MedlinePgn>543-548</MedlinePgn>
</Pagination>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.schres.2017.09.003</ELocationID>
<Abstract><AbstractText>Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. Specifically, most UHR individuals will not develop psychosis, but will experience high rates of non-psychotic disorders, persistent APS and poor long-term functional outcomes. Rather than focus on transition, the present study investigated whether UHR groups differ in their broader clinical risk profile by examining baseline clinical characteristics and long-term outcomes other than transition to psychosis. Four UHR groups were defined: Trait-only, APS-only, Trait+APS, and any BLIPS. Participants (N=702) were recruited upon entry to early intervention services and followed-up over a period of up to 13years (mean=4.53, SD=3.84). The groups evidenced similar symptom severity (SANS for negative symptoms, BPRS for positive and depression/anxiety symptoms) and psychosocial functioning (SOFAS, GAF, QLS) at baseline and follow-up as well as similar prevalence of non-psychotic disorders at follow-up. Our findings demonstrate that UHR groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis, and consequently support maintaining the existing UHR criteria.</AbstractText>
<CopyrightInformation>Copyright © 2017. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McHugh</LastName>
<ForeName>M J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre for Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia. Electronic address: meredith.mchugh@gmail.com.</Affiliation>
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</AffiliationInfo>
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<ForeName>I B</ForeName>
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<AffiliationInfo><Affiliation>Brain and Mind Centre, University of Sydney, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
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<Initials>A</Initials>
<AffiliationInfo><Affiliation>Division of Mental Health and Wellbeing, The University of Warwick, Coventry, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Haan</LastName>
<ForeName>L</ForeName>
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<AffiliationInfo><Affiliation>Department of Psychiatry, Early Psychosis Section, Academic Medical Centre, University of Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mossaheb</LastName>
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<ForeName>M</ForeName>
<Initials>M</Initials>
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<ForeName>M</ForeName>
<Initials>M</Initials>
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<Month>10</Month>
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The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo.

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo.

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